PINTS finds similarities between protein structures consisting of amino acids that are close in space, but not necessarily close or co-linear in sequence (local structural patterns, for example the catalytic triad). Unlike other tools, PINTS does not aim to find proteins adopting a similar fold.
This server allows you to compare a protein structure against a database of patterns or a structural pattern (up to 100 amino acids) against a database of protein structures. In addition, you can compare two proteins to one another. Input format is the normal PDB text format; i.e. you can directly upload your structure or - for publicly available structures - specify PDB identifiers and chain.
Matches are evaluated by RMSD (root-mean-square deviation) and a statistical E-value.
See HELP, INFO, or FAQs for more information.
Please cite: A. Stark, S. Sunyaev, R.B. Russell, 'A model for statistical significance of local similarities in structure', J. Mol. Biol, 326, 1307-1316, 2003.
Download: source code.
Please contact us with suggestions or problems concerning the server or the method.
© Alexander Stark and Robert B. Russell, 2002, 2003
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