Matthew Betts

History

• 2006-Now Computational Biologist, Russell Group (Structural Bioinformatics), EMBL, Heidelberg, Germany
• 2005-2006 Postdoc, Russell Group (Structural Bioinformatics), EMBL, Heidelberg, Germany
• 2003-2005 Postdoc, Liberles Group, CBU, BCCS, UNIFOB / UiB, Bergen, Norway
• 2001-2003 Research Scientist, Bioinformatics, deCODE Genetics, Iceland
• 2000 Contractor, Bioinformatics, SmithKline Beecham, UK (supervisor: Rob Russell)
• 1998-2000 Research Assistant, MRC LMB, Cambridge, UK (supervisor: Rodger Staden)
• 1999 PhD, Analysis and Prediction of Protein-Protein Docking, ICRF, London, UK (supervisor: Mike Sternberg)
• 1994 MSc, Computer Modelling of Molecular and Biological Processes, Birkbeck College, London, UK
• 1993 BSc (Hons), Chemistry, York University, UK

Refereed Articles

1. Arnesen T, Starheim KK, Van Damme P, Evjenth R, Dinh H, Betts MJ, Ryningen A, Vandekerckhove J, Gevaert K, Anderson D, 'The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation.', Mol Cell Biol. 2010 Apr;30(8):1898-909. Epub 2010 Feb 12.
2. Kuhner S, van Noort V, Betts MJ, Leo-Macias A, Batisse C, Rode M, Yamada T, Maier T, Bader S, Beltran-Alvarez P, Castano-Diez D, Chen WH, Devos D, Guell M, Norambuena T, Racke I, Rybin V, Schmidt A, Yus E, Aebersold R, Herrmann R, Bottcher B, Frangakis AS, Russell RB, Serrano L, Bork P, Gavin AC, 'Proteome organization in a genome-reduced bacterium.', Science. 2009 Nov 27;326(5957):1235-40.
3. Arnesen T, Gromyko D, Kagabo D, Betts MJ, Starheim KK, Varhaug JE, Anderson D, Lillehaug JR, 'A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1).', BMC Biochem. 2009 May 29;10:15.
4. Al-Amoudi A, Diez DC, Betts MJ, Frangakis AS, 'The molecular architecture of cadherins in native epidermal desmosomes.', Nature. 2007 Dec 6;450(7171):832-7.
5. Moelleken J, Malsam J, Betts MJ, Movafeghi A, Reckmann I, Meissner I, Hellwig A, Russell RB, Sollner T, Brugger B, Wieland FT, 'Differential localization of coatomer complex isoforms within the Golgi apparatus.', Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4425-30. Epub 2007 Mar 7.
6. Berglund-Sonnhammer AC, Steffansson P, Betts MJ, Liberles DA, 'Optimal gene trees from sequences and species trees using a soft interpretation of parsimony.', J Mol Evol. 2006 Aug;63(2):240-50. Epub 2006 Jul 7.
7. Arnesen T, Betts MJ, Pendino F, Liberles DA, Anderson D, Caro J, Kong X, Varhaug JE, Lillehaug JR, 'Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.', BMC Biochem. 2006 Apr 25;7:13.
8. Roth C, Betts MJ, Steffansson P, Saelensminde G, Liberles DA, 'The Adaptive Evolution Database (TAED): a phylogeny based tool for comparative genomics.', Nucleic Acids Res. 2005 Jan 1;33(Database issue):D495-7.
9. Bonfield JK, Beal KF, Betts MJ, Staden R, 'Trev: a DNA trace editor and viewer.', Bioinformatics. 2002 Jan;18(1):194-5.
10. Betts MJ, Guigo R, Agarwal P, Russell RB, 'Exon structure conservation despite low sequence similarity: a relic of dramatic events in evolution?', EMBO J. 2001 Oct 1;20(19):5354-60.
11. Betts MJ & Sternberg MJ, 'An analysis of conformational changes on protein-protein association: implications for predictive docking.', Protein Eng. 1999 Apr;12(4):271-83.

Other Publications

1. Betts MJ & Russell RB, 'A more structured metabolome.', Nat Struct Mol Biol. 2009 Nov;16(11):1125-6.
2. Betts MJ & Russell RB, 'The hard cell: from proteomics to a whole cell model.', FEBS Lett. 2007 Jun 19;581(15):2870-6. Epub 2007 May 30.
3. Roth C, Betts MJ, Liberles DA, 'Protein content in chordate and embryophyte genomes.', In: Trends in Bioinformatics Research, Yan P (editor), Nova Science Publishers, Inc., 2005.
4. Betts MJ & Russell RB, 'Amino acid properties and consequences of substitutions', In: Bioinformatics for Geneticists, Barnes & Gray (editors), Wiley (2003).